Next Generation DNA Sequencing technologies are facilitating new approaches for drug discovery and development. Human genetics is the foundation of disease as well as the response to pharmaceutical agents. Today, Next Generation DNA Sequencing technologies promising drugs are abandoned due to the lack of significant efficacy in broad patient populations. Recently, blockbuster drugs have been removed from the market due to unexplained toxicity not revealed in clinical.
The importance of this Next Generation DNA Sequencing technology is exemplified by the fact that more than 120 studies have been published since the introduction of the first next generation sequencing technology. Publication of novel information is a significant validation for the technology and many of the applications have direct relevance to drug discovery and development. Importantly, the next generation sequencing has facilitated new research approaches including the whole genome analysis of disease causing organisms, the comprehensive study of small and micro-RNA populations.
Advancements in molecular medicine due to next generation sequencing is not limited to the new study of small RNAs but also includes other areas in which the deep sequencing of a population of molecules is essential to the understanding of the molecular processes at work. Drug resistance is one area in particular that will benefit from the application of next generation dna sequencing. The application of deep sequencing for drug resistance has been applied to infectious agents such as Mycobacterium tuberculosis, Staphylococcus aureus and HIV in DNA Sequencing History. The next generation sequencing platforms make the sequencing of whole bacterial genomes a routine practice.
The application of next generation dna sequencing to HIV research is extremely powerful because the virus rapidly mutates as a part of its normal biology. The massive throughput enabled by these platforms has allowed researchers to dig deeply into the metagenome of a viral population and identify all subtypes of virus present. The ability to sequence a viral genome thousands of times on a single sequencing run makes them an ideal tool for anti-viral research.
Integration of DNA sequencing into the drug discovery process will allow the identification of specific patient populations as well as identifying diagnostic and/or theranostic markers. DNA sequencing offers the most reliable and accurate method of grouping individuals into characteristic genetic profiles. Next Generation DNA Sequencing Technologies of disease-associated regions enables the differentiation of genetic profiles, regardless of the underlying genetic changes. Up until now, DNA sequencing has been of limited use in clinical trials because of the prohibitive cost and amount of time associated with sequencing the hundreds of individual.
The importance of this Next Generation DNA Sequencing technology is exemplified by the fact that more than 120 studies have been published since the introduction of the first next generation sequencing technology. Publication of novel information is a significant validation for the technology and many of the applications have direct relevance to drug discovery and development. Importantly, the next generation sequencing has facilitated new research approaches including the whole genome analysis of disease causing organisms, the comprehensive study of small and micro-RNA populations.
Advancements in molecular medicine due to next generation sequencing is not limited to the new study of small RNAs but also includes other areas in which the deep sequencing of a population of molecules is essential to the understanding of the molecular processes at work. Drug resistance is one area in particular that will benefit from the application of next generation dna sequencing. The application of deep sequencing for drug resistance has been applied to infectious agents such as Mycobacterium tuberculosis, Staphylococcus aureus and HIV in DNA Sequencing History. The next generation sequencing platforms make the sequencing of whole bacterial genomes a routine practice.
The application of next generation dna sequencing to HIV research is extremely powerful because the virus rapidly mutates as a part of its normal biology. The massive throughput enabled by these platforms has allowed researchers to dig deeply into the metagenome of a viral population and identify all subtypes of virus present. The ability to sequence a viral genome thousands of times on a single sequencing run makes them an ideal tool for anti-viral research.
Integration of DNA sequencing into the drug discovery process will allow the identification of specific patient populations as well as identifying diagnostic and/or theranostic markers. DNA sequencing offers the most reliable and accurate method of grouping individuals into characteristic genetic profiles. Next Generation DNA Sequencing Technologies of disease-associated regions enables the differentiation of genetic profiles, regardless of the underlying genetic changes. Up until now, DNA sequencing has been of limited use in clinical trials because of the prohibitive cost and amount of time associated with sequencing the hundreds of individual.
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